5-Pregnen-3B-ol-20-one-17a,21,21,21-d4 3-Methyl Ether
1-[(3S,8S,9S,10R,13R,14S,17S)-3-methoxy-10,13-dimethyl-2,3,4,7,8,9,11, 12,14,15,16,17-dodecahydro-1H-cyclopenta[a]phenanthren-17-yl]ethanone
CAS: 511-26-2
Molecular Formula: C22H34O2
5-Pregnen-3B-ol-20-one-17a,21,21,21-d4 3-Methyl Ether - Names and Identifiers
5-Pregnen-3B-ol-20-one-17a,21,21,21-d4 3-Methyl Ether - Physico-chemical Properties
| Molecular Formula | C22H34O2 |
| Molar Mass | 330.5 |
| Melting Point | 123.5° |
| Specific Rotation(α) | D18 +18° (c = 1.085 in chloroform) |
| In vitro study | MAP4343 (40 μM; 15 or 30 min) stimulates microtubule polymerization in vitro. MAP4343 (30 μM; 2-8 d) stimulates nerve growth factor (NGF)-induced neurite outgrowth in PC12 cells. MAP4343 (20 μM; 1 h) protects against microtubule depolymerization induced by Nocodazole in PC12 cells |
5-Pregnen-3B-ol-20-one-17a,21,21,21-d4 3-Methyl Ether - References
| biological activity | MAP4343 is a 3-methyl ether derivative of pregnenalone. MAP4343 binds to microtubule-associated protein 2 (MAP2) in vitro, stimulates tubulin polymerization, enhances neurite elongation and protects neurons from neurotoxic agents. |
| Animal Model: | Adult Sprague-Dawley male rats with spinal cord injury |
| Dosage: | 12 mg/kg |
| Administration: | Daily s.c. for 28 days |
| Result: | Increased the number of animals able to walk with weight-supported plantar steps. Showed forelimb-hindlimb coordination at the end of the study. |
Last Update：2024-04-09 15:17:17
